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Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

MedGen UID:
818206
Concept ID:
C3812874
Neoplastic Process
Synonyms: Atypical Endometrial Hyperplasia; Atypical Hyperplasia of Endometrium; Atypical hyperplasia of the endometrium; Atypical Hyperplasia of the Endometrium; Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasm; EIN - endometrial intraepithelial neoplasia; Endometrial Glandular Dysplasia; Endometrial Hyperplasia with Atypia; Endometrial Intraepithelial Neoplasia; Endometrial intraepithelial neoplasia; Endometrioid intraepithelial neoplasia
SNOMED CT: Endometrial intraepithelial neoplasia (419327006); EIN - endometrial intraepithelial neoplasia (419327006); Atypical hyperplasia of the endometrium (703548001); Endometrioid intraepithelial neoplasia (703548001)

Definition

A neoplastic clonal expansion of endometrial glands characterized by cytologic changes of the epithelium and the presence of an increased number of endometrial glands. The glands form crowded aggregates with tubular or branching patterns which are cytologically distinct from the background architectural and cytological pattern. It is associated with molecular changes seen in endometrioid endometrial carcinoma, including microsatellite instability, PAX2 inactivation, and PTEN, KRAS, and CTNNB1 gene mutations. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

Professional guidelines

PubMed

Travaglino A, Raffone A, Saccone G, Mascolo M, Pignatiello S, Mollo A, De Placido G, Insabato L, Zullo F
APMIS 2019 Apr;127(4):161-169. doi: 10.1111/apm.12938. PMID: 30803040

Recent clinical studies

Etiology

Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH
Am J Surg Pathol 2022 Mar 1;46(3):404-414. doi: 10.1097/PAS.0000000000001810. PMID: 34545858Free PMC Article

Diagnosis

Bian PP, Liu SY, Luo QP, Xiong ZT
Pathol Res Pract 2022 Jun;234:153919. Epub 2022 Apr 28 doi: 10.1016/j.prp.2022.153919. PMID: 35512522
Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH
Am J Surg Pathol 2022 Mar 1;46(3):404-414. doi: 10.1097/PAS.0000000000001810. PMID: 34545858Free PMC Article
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

Prognosis

Sharma AE, Moran A, Somasegar S, Steinhardt G, Chapel DB, Lastra RR, Lee NK, Ritterhouse LL, Bennett JA
Int J Gynecol Pathol 2023 Jan 1;42(1):26-34. Epub 2022 Feb 4 doi: 10.1097/PGP.0000000000000856. PMID: 35125405
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

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